Eleven genes we report, however, predispose to the same conditions as listed on “ACMG59”, such as breast cancer (BRIP1, five UFs) and cardiac disease (CSRP3, one UF), or predispose to conditions that fall in the same phenotypic spectrum of diseases, such as renal cancer (FH, one UF) and pulmonary hypertension (BMPR2, one UF). This evidence concerns the gene BRIP1 and breast carcinoma.