AIM2 and bacterial infectious disease: In addition to PKM2-mediated glycolysis in macrophages, which promotes both NLRP3 and AIM2 inflammasome activation [78], Cho et al. recently demonstrated a novel mechanism by which activation of the AIM2 inflammasome links glucose transporter 1 (GLUT1)-mediated glycolysis to regulate the acute exacerbation of lung fibrogenesis during bacterial infection [191].