Sepsis is an overreactive host immune response to microbial infection that results in dysregulated systemic inflammation accompanied by the secretion of multiple proinflammatory mediators, such as TNF, IL-1β, and high mobility group Box 1 (HMGB1) [189]; sepsis has also been linked to immunometabolism in macrophages. This evidence concerns the gene HMGB1 and Sepsis.