Interestingly, NLRX1 is also expressed by CD4+ T cells, and the loss of NLRX1 results in increased disease severity and increased numbers of Th1 and Th17 cells producing inflammatory cytokines (IFN-γ, TNF, and IL-17) in dextran sodium sulfate-induced (DSS) colitis. The gene discussed is NLRX1; the disease is colitis.