Accordingly, in bone marrow-derived macrophages (BMDMs), glycolytic disruption caused by the small molecule GB111-NH2 or infection with Salmonella typhimurium induced NLRP3 inflammasome formation, IL-1β secretion, and pyroptotic cell death via a mechanism involving mtROS production and impaired NADH formation mediated by glycolysis [89]. The gene discussed is IL1B; the disease is infection.