In conclusion, our study demonstrates that LDMC-induced REDD1 causes functional dysregulation of tumor-associated vascular and lymphatic endothelial cells through selective translational repression of Vegfr-2/3 mRNAs, which in turn inhibits the formation of tumor blood and lymphatic vascular networks and promotes tumor vascular normalization and a favorable tumor microenvironment (Fig. 7i). Here, DDIT4 is linked to neoplasm.