Thus, the REDD1-mTORC1-VEGFR-2/3 axis is crucial for LDMC-induced tumor therapeutic efficacy and supports the notion that REDD1 is an LDMC-sensitive molecular sensor that modulates phenotypic switching of endothelial cells from angiogenic and lymphangiogenic phenotypes to angiostatic and lymphangiostatic states. Here, KDR is linked to neoplasm.