To address the possible link between inhibition of tumor angiogenesis and increased REDD1 expression by LDMC3,7, we treated HUVECs and HLECs with noncytotoxic low-dose DOX (3 nM), whose concentration was determined by MTT-based mitochondrial activity and lactate dehydrogenase release assays (Supplementary Fig. 1a, b), and found a significant upregulation of REDD1 at the mRNA and protein levels (Fig. 1a, b). This evidence concerns the gene DDIT4 and neoplasm.