GPT and obesity due to melanocortin 4 receptor deficiency: However, the amphotericin B-pretreated HFD-fed mice receiving live C. parapsilosis exhibited dramatic features of obesity, as indicated by the increased body weight and fat accumulation, the higher levels of plasma FFA, TG, TC, LDL-C, the enhanced activity of AST and ALT, and the increased hepatic lipid deposition (Fig. 3e–m).