GPT and obesity due to melanocortin 4 receptor deficiency: In contrast to the obesity and obesity-related disorders observed in the CPWT-treated group, the body weight gain, the size of adipose tissue, the levels of plasma TC, TG, FFA, the levels of hepatic TC and TG, the levels of AST and ALT, and the degree of hepatic steatosis in the CPKO-treated group were little influenced (Fig. 5b–j).