Moreover, the correlation between p65 expression with a reduction in the ratio between Th1/Th2 and Th17/Treg immune responses during pregnancy, which was not observed during IUGR, suggests that lymphocytes are endogenously polarised towards a Th1 and Th17 pro-inflammatory profile during IUGR, and for Th1, this is mediated through dysregulation of p65. This evidence concerns the gene RELA and fetal growth restriction.