TNF and type 1 diabetes mellitus: The nodes of the PPI network demonstrated 39 nodes for the pathway of Th17 cell differentiation, 26 nodes for type 1 diabetes mellitus, 30 nodes for Th1 and Th2 cell differentiation, 30 nodes for NF-kappa B signaling pathway, 31 nodes for Apoptosis, and 28 nodes for TNF signaling pathway (Table S10).