Genes APP, CASP3, CTNNB1, EGFR, IGF1R, STAT3, and TGFBR2 were hub proteins which were targeted by more than 10 T1D-related miRNAs, whereas miRNAs miR-155-5p, miR-34a-5p, miR-23b-3p, miR-20a-5p, miR-103a-3p, miR-24-3p, miR-181a-5p, and miR-23a-3p were hub miRNAs which targeted more than 12 backbone proteins in the gene-miRNA network (Fig. 3). This evidence concerns the gene CASP3 and type 1 diabetes mellitus.