PPARG and neoplasm: The observations that (i) number of tumors with the mixed basal/luminal subtype increases with time, (ii) that these tumors express Pparg both in luminal and basal-like domains (iii) that both luminal and basal domains are Gfp positive, suggests that lower basal-like domain derived from the upper luminal tumor, and had begun to shift from a luminal to a basal subtype.