KRT14 and neoplasm: Expression of the VP16;Pparg transgene in K14-Basal cells during homeostasis induces a terminal differentiation program, however, we find that a short period of exposure to BBN, a carcinogen or cyclophosphamide that contains acrolein alters the urothelial microenvironment, inducing an inflammatory response that may prime K14-basal cells for tumor formation.