ESR1 and neoplasm: Since cytokines such as CXCL12, IGFBP2 and GDF15 can be regulated by both ER and STAT3, it is conceivable that these cytokines, in addition to anti-apoptotic genes, can be kept producing in the elevated Lnc-DC background such that these tumor cells can survive and grow even when ER signaling is shut down by clinical intervention such as estrogen deprivation or tamoxifen treatment (Fig. 6D).