SARS-CoV-2 typically infects the upper and lower respiratory tracts, causing direct cytotoxic effects and local cytokine-mediated hyperinflammation and acute respiratory distress syndrome (ARDS).1,2 The spike (S) protein mediates the entry of the SARS-CoV-2 into the cell and is the most important antigen of the virus.3 Multiple vaccines using various vaccine platforms or neutralizing monoclonal antibodies (mAbs) that target the S protein of SARS-CoV-2 have already been explored for clinical usage to prevent SARS-CoV-2 infection.4 Vaccines are protective but take time to be effective. The gene discussed is CHMP5; the disease is acute respiratory distress syndrome.