PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) is a nuclear protein serine/threonine kinase that is a molecular sensor of DNA damage, which has been shown to play important roles in the disease process of a variety of tumors, including breast cancer, colorectal cancer, and prostate cancer [18–20]. Here, PRKDC is linked to Familial prostate cancer.