We used IP and co-IP assays to confirm the interaction between ZBTB38 and PRKDC. In vitro assay indicated that PRKDC knockdown resulted in an increase of DKK1 expression and enhanced the tumor-suppressive function of ZBTB38, which suggested that PRKDC could inhibit the tumor-suppressive function of ZBTB38. The interaction of PRKDC and ZBTB38 is quite interesting. The gene discussed is ZBTB38; the disease is neoplasm.