Loss-of-function of RBPs has been previously explored with another member of the hnRNP family of RBPs known as TAR-DNA-binding protein-43 (TDP-43), where nuclear clearance of TDP-43 has been shown to induce DNA double stranded break repair defects in ALS (Mitra et al., 2019) and exacerbate neurodegeneration in an AD mouse model (LaClair et al., 2016; Steinacker et al., 2019; Huang et al., 2020; Masaki et al., 2020). Here, TARDBP is linked to Alzheimer disease.