TARDBP and frontotemporal dementia: Frontotemporal dementia (FTD) and related disorders comprise a clinically and pathologically heterogeneous group of neurodegenerative disorders that are characterized by progressive atrophy of the frontal and temporal lobes with relative sparing of the posterior cerebral regions, and abnormal molecular accumulations, mostly commonly of tau or TDP-43 (Seelaar et al., 2011).