Factors for spontaneous arterial limb occlusion include perinatal asphyxia, respiratory distress syndrome, maternal diabetes, neonatal sepsis, necrotizing enterocolitis, clotting disorders such as factor V Leiden, dehydration, congenital nephrotic syndrome, polycythemia, and twin–twin transfusion syndrome [6]. The gene discussed is F5; the disease is familial nephrotic syndrome.