TLR4 and multiple sclerosis: A cytokines cocktail known to exert pro-inflammatory effects in the CNS of multiple sclerosis animal models [4, 11, 13] and LPS, a toll- like receptors (TLR) agonist, in particular of TLR4, expressed on the microglia surface, that influence cytokine production and immune cell function mimicking systemic inflammation [11, 13, 17].