Then, circ_0004296 had relatively high expression abundance (Figure S1A); compared to that in prostate normal cells, circ_0004296 expression was significantly downregulated in all PCa cell lines (Fig. 1B and S1B-D); its host gene ETS1 was abnormally high expression and is an oncogenic gene in PCa, which suggests that the low expression of circ_0004296 may be functional. The gene discussed is ETS1; the disease is posterior cortical atrophy.