Additionally, PDX1-rs11619319 (OR = 0.51, 95% CI = 0.27–20.97, p = 0.039) and rs2293941 (OR = 0.51, 95% CI = 0.27–0.97, p = 0.040) were predominantly related to a reduced risk of T2DM among drinkers under the codominant model. This evidence concerns the gene PDX1 and type 2 diabetes mellitus.