We identified four polymorphisms in PDX1 (rs11619319, rs2293941, rs9581943 and rs7981781) and six polymorphisms in MC4R (rs6567160, rs663129, rs17782313, rs12969709, rs11663816, and rs12970134) to investigate the correlations between genetic polymorphisms and T2DM susceptibility. Here, PDX1 is linked to type 2 diabetes mellitus.