PDX1 and type 2 diabetes mellitus: In addition, as shown in Table 4, PDX1-rs7981781 reduced the susceptibility to T2DM among smokers under the codominant (OR = 0.50, 95% CI = 0.29–0.89, p = 0.018) and dominant (OR = 0.55, 95% CI = 0.32–0.95, p = 0.030) models.