In addition, Myc directly bound the super-enhancer and promoter region of TMEM44-AS1 and enhanced its activation; the interaction of Myc with MED1 then reciprocally triggers the epigenetic activation of TMEM44-AS1 transcription, thus forming a positive feedback loop between TMEM44-AS1 and Myc/MED1 in glioma. The gene discussed is TMEM44; the disease is central nervous system cancer.