APP and Alzheimer disease: In present study, using the NSCs overexpressed amyloid precursor protein (APP-NSCs) as the AD cell model [29, 30], we sought to investigate the potential beneficial effects of the three active constituents of PT mentioned above on the survival, proliferation and differentiation of APP-NSCs in vitro, and further evaluate the effects of the potential active constituent DISS on the hippocampal neurogenesis in adult APP/PS1 transgenic mice.