SPI1 and infection: sipC protein which forms an important component of translocon of the T3SS and is required for an efficient SPI1 effector release was also investigated.42 In line with the above data, infection with a Salmonella sipC mutant (ΔsipC), also did not lead to H3K27me3 levels decrease (Figure 3f), in spite of increased expression of KDM6B (Figure 3g).