PPARD and colorectal cancer: A recent study, wherein PPARδ was expressed under the control of villin-gene promoter in mice, has shown spontaneous development of invasive gastric adenocarcinomas highlighting the propensity of PPARδ to be carcinogenic.59 However, the role of PPARδ in APC heterozygous mice for development of colorectal cancer is quite controversial.60 KDM6B upregulation in intestinal crypts and PPARδ being its target and other identified WNT pathway genes, asshown in the above work, makes an interesting area of study in understanding long-term consequences of chronic Salmonella infection.