KDM6B mRNA expression increased in all the treatments in comparison to control group (Figure 3b), however surprisingly the H3K27me3 levels remained unchanged on exposure to LPS, HKS and ΔSPI1.Only infection with wild-type Salmonella and ΔSPI2 displayed decrease in H3K27me3 (Figure 3c), thus indicating involvement of SPI1 effectors in loss of H3k27me3 levels. The gene discussed is SPI1; the disease is infection.