KDM6B is a histone demethylase belonging to JmjC domain containing family of histone demethylases known to specifically remove methyl group from trimethylated H3K27 (H3K27me3) at gene promoters leading to their activation.36,37 Expression analysis at different time intervals post Salmonella infection in HCT-8 cells showed a statistically significant increase in KDM6B expression with maximal expression at 4 h p.i. (Figure 1b). This evidence concerns the gene KDM6B and Salmonella Infections.