In this study, to investigate other miRNAs targeting MMP13, we hypothesized that miR-4423-3p targets MMP13, and explored the effect of miR-4423-3p targeting MMP13 on cells using HFLS-RA to evaluate whether miR-4423-3p has the potential to be a therapeutic target for RA. The gene discussed is MMP13; the disease is rheumatoid arthritis.