Our analysis on the long-term recurrence rates and OS rates of patients with different AFP and sICAM-1 levels showed that the patients with AFP > 200 μg/L or sICAM-1 > 2000 μg/L had lower TFS rates and OS rates than the patients with AFP < 200 μg/L or sICAM-1 < 2000 μg/L in primary HCC. Here, AFP is linked to hepatocellular carcinoma.