CCND1 and familial pancreatic carcinoma: Furthermore, the USMB co-treated with RFA resulted in significantly higher reduction of Bcl-2, survivin and CyclinD1 expression and increase of Bax and caspase-3 expression compared to USMB or RFA treatment alone, suggesting that USMB synergizes with RFA to regulate the expression of the above apoptosis-related proteins and then jointly promote tumor cell apoptosis, inhibit cell proliferation, and finally inhibit the growth of subcutaneous xenografts of pancreatic cancer cell line Panc02.