CASP3 and neoplasm: In this study, USMB combined with RFA treatment significantly down-regulated the expression of Bcl-2, survivin and CyclinD1, and up-regulated the expression of BAX and caspase-3 in xenograft of Panc02-bearing mice, indicating that the combination of USMB and RFA can inhibit the proliferation of tumor cells by promoting apoptosis (Figure 6).