Furthermore, the USMB co-treated with RFA resulted in significantly higher reduction of Bcl-2, survivin and CyclinD1 expression and increase of Bax and caspase-3 expression compared to USMB or RFA treatment alone, suggesting that USMB synergizes with RFA to regulate the expression of the above apoptosis-related proteins and then jointly promote tumor cell apoptosis, inhibit cell proliferation, and finally inhibit the growth of subcutaneous xenografts of pancreatic cancer cell line Panc02. The gene discussed is BCL2; the disease is neoplasm.