上述各SCLC亚型中,SCLC-A和SCLC-N属于NE类型,肿瘤细胞具有典型的神经内分泌特征,能够表达嗜铬粒素A(chromogranin A, ChgA)和突触素(synaptophysin, SYP)等NE标志物;而SCLC-P和SCLC-I属于Non-NE类型,不表达ChgA和SYP,但高表达REST等[12]。. The gene discussed is REST; the disease is small cell lung carcinoma.