MIF and immune system disorder: Besides the Balb/C nude mice immunodeficiency due to thymus absence, the cytokines and chemokines phenotype after ZIKVBR systemic treatment showed the downregulation of metastasis inducers, GPI1 and VEGFA, and the macrophages migration inhibitory factor (MIF), key regulators in tumorigenesis, angiogenesis, and tumor metastasis [22].