When considering the opposite signaling, we observed an upregulation of Hc cytokine, tumor necrosis factor ligand superfamily member 13b (Tnfsf13b), and the anti-inflammatory cytokine IL-6 only in mice injected with USP7ATRT tumor cells and treated with three systemic injections of ZIKVBR (Figure 5C). This evidence concerns the gene IL6 and neoplasm.