CSF2 and pachyonychia congenita: The oncolytic viruses, the efficacy of which has been or is being tested in clinical trials against PC, include oncolytic Adenoviruses armed with Interleukin-12 (IL-12) or granulocyte macrophage colony-stimulating factor (GM-CSF), and Reolysin (natural human virus), also in combination with ICIs [13], (see for examples Clinicaltrials.gov reference NCT02555397, NCT02555397, NCT03514836, NCT01619813).