To provide the first proof-of-principle evidence that R-405 exerts antitumor efficacy against PSMA-positive tumors in syngeneic murine models, we made use of the LLC1-PSMA and Renca-PSMA tumor cells described above, syngeneic with C57BL/6 and BALB/c mice, respectively. Here, FOLH1 is linked to neoplasm.