All three Rho GTPases, RHOA, CDC42, and RAC1, showed a significant decrease in gene expression upon age in COVID-19 patients (Figure 2A.II,B.II,C.II; p-trend decreasing = 0.002, p-trend decreasing = 0.008, p-trend decreasing = 0.004, respectively). The gene discussed is RAC1; the disease is COVID-19.