MYC and infection: Data from Smallwood et al. [22] indicate that infection-associated increases of PI3K/mechanistic target of rapamycin (mTOR) signaling and the expression of the transcription factor MYC (formerly c-MYC), a key regulator of glycolytic genes [67], are largely responsible for the reprogramming of glycolysis and glutaminolysis, which resulted in elevated viral titers [22].