Here, we used live and heat-inactivated DENV2 to infect lung cancer cells A549 [31] and demonstrated that the conversion of the autophagy marker LC3-II protein increased, which was accompanied by a higher level of DENV2 NS3 protein in the DENV2 infection cells compared to the non-infection (Mock) and heat-inactivated DENV (iDENV2) cells (Figure 1A). This evidence concerns the gene KRAS and lung carcinoma.