IRF3 and infection: IRF-3 should induce expression of type I IFNs; however, compared to WR-Luc, the inoculation of WR-IRF3 induced only a limited increase in IFNβ (Figure 7a) and IFNα mRNA levels (Figure S5a) at 2 days p.i., while their total levels revealed a stagnation at day 4 p.i. With the exception of IL-12, upon infection with WR-IRF3, the levels of other mRNAs tended to decrease or normalize back to the levels found in mock-inoculated Nc/Nga mice within 4 days p.i. (Figure 7b and S5).