In addition, HC-Pro from three potyviruses, including potato virus A (PVA), PVY, and TEV could interact with the eukaryotic translation initiation factors (eIF4E) and eIF(iso)4E of Nicotiana tabacum and eIF(iso)4E and eIF4E of potato suggesting possible new role(s) in potyvirus infection cycle [55]. The gene discussed is EIF4E; the disease is infection.