Since HSV-2 was detected in fetuses by qPCR and IHC, we next investigated whether viral infection in fetal tissues stimulated the production of inflammatory cytokines and chemokines using the same analytes detected in decidual and placental tissues: IL-1α, IL1-β, IL-6, TNF-α, MIP-1α, MIP-1β, MIP-2, G-CSF, and KC (CXCL1). This evidence concerns the gene CCL4 and viral infectious disease.