Based on these facts, if we assume that these two patients [2,3] express any of these very specific receptors such as CD15, CD27, CD45, and CD152 that are not commonly expressed in cHL and FL, and that the SARS-CoV-2 Spike-RBD may bind to any of these receptors like a mAb and thereafter works in a similar fashion to brentuximab vedotin (SGN-35 or Adcetris), this suggests a possible molecular mechanism of the remission of the lymphoma patients as described by Challenor and Tucker [2] and Sollini et al. [3]. The gene discussed is CTLA4; the disease is lymphoma.