Although we do not know if the reported cHL and FL cases [2,3] are PD-1 positive, we analyzed whether the SARS-CoV-2 Spike protein may act like pembrolizumab and nivolumab, which bind to PD-1 to block the access of PDL-1 and PDL-2 and thus downregulate PD-1 signaling and induce apoptosis. The gene discussed is PDCD1LG2; the disease is classic Hodgkin lymphoma.