The cHL patient of Challenor and Tucker was EBV positive [2], and the LMP-1 of EBV is the main oncogenic protein of EBV that activates oncogenic signaling through activation of NF-κB, JAK/STAT, and PI3K/AKT pathways through its cytoplasmic TRAFs and TRADD binding motifs [23,26]. Here, NFKB1 is linked to classic Hodgkin lymphoma.