IL1B and pyruvate dehydrogenase deficiency: As there was an increase of CD3+ and CD11c+ cells (Figure 4G), but a reduction of IL1β+CD11c+ and IL1β+CD3+ cell (Figure 4I) in the TME of PD-H compared to control mice, IL-1β-expressing CD3+ and DC cells were specifically reduced in the TME of PD-H mice.