hDlg, hScrib and MAGI-1 are tumour suppressors; the loss of these proteins facilitates cancer formation (reviewed in [275,276]), and all high-risk E6 proteins target them for proteasome-mediated degradation [272,277,278], most likely leading to the loss of cell polarity and facilitating tumour formation [279,280]. The gene discussed is SCRIB; the disease is cancer.