On the other hand, binding of high-risk E6 oncoprotein to Sorting Nexin 27 (SNX27), an important regulator of the endosomal retromer complex, has been shown to upregulate glucose uptake by cancer cells by modulating the expression of GLUT1 [305], leading to increased glycolytic flux in cervical cancer cells. The gene discussed is SNX27; the disease is cervical cancer.