SCRIB and cancer: Indeed, the degree of interaction with hScrib and another member of the apico-basal polarity (ABP) core component—the tight junction (TJ) protein ZO-2—is highly associated with a stronger cancer association (HPV-16, -18, -31, -35 and -51), suggesting that perturbation of the Scrib ABP complex is one of the crucial steps towards malignant transformation driven by E6 oncoprotein [282].