The deletion of KLF2 in all myeloid cells by the use of the Lyz2-cre deleter identified KLF2 as a central regulator of innate immune responses to bacterial infections and septic shock (Table A1) and connected KLF2 expression to hypoxia, HIF-1α and NF-κB signaling networks. The gene discussed is KLF2; the disease is bacterial infectious disease.