Activation of interferon signaling has been observed to induce the expression of various antiviral proteins such as interferon-induced transmembrane protein 1 (IFITM1), interferon-induced protein with tetratricopeptide repeats (IFIT3), IFN-α inducible gene 6 (IFI6), 2′-5′-oligoadenylate synthetase 2 (OAS2), adenosine deaminases acting on RNA (ADAR), interferon-β (IFNβ), and tripartite motif containing 25 (TRIM25), which play a role in attenuating viral replication and the oncolysis of tumor cells [69]. This evidence concerns the gene IFI6 and neoplasm.