Through this approach, we found that there has been a selective focus on assessing interferon (IFN)-mediated resistance by tumor cells (twenty-seven studies), with only two studies reporting on the role of fibroblast-mediated resistance [7,8] and three other studies assessing the role of epithelial cells and endothelial cells as physical barriers in regulating the spatiotemporal spread of the virus in tumors [9,10,11] (Figure 3B). The gene discussed is IFNA1; the disease is neoplasm.