Then, we tried to assess the correlation of circPRKCI, miR-20a-5p, and SOX4 in the modulation of T-ALL cell survival in vitro. As expected, the MOLT-4 and JURKAT cell viability was reduced by circPRKCI silencing, while the overexpression of SOX4 or suppression of miR-20a-5p rescued the reduced viability in MOLT-4 and JURKAT cells (Figure 7A, 7B). This evidence concerns the gene SOX4 and acute lymphoblastic leukemia.