CXCR6 and Salmonella Infections: In considering previous reports where CXCR3 and CCR5 [25,27] compensated for some effects of CXCR6 deficiency in Th1 cells, and that the impact of CXCR6 on liver homing by CD8+ T cells can change over time [28–30], we conclude that the role of CXCR6 in liver immunity to Salmonella infection is complex and as such requires further investigation to fully explain the role of the chemokine and its ligand in cell accumulation in this organ.