The European Society Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines [7] and European Society for the Study of Coeliac Disease (ESsCD) guidelines [8] suggest that biopsies can be avoided in children who have high tTG-IgA levels and a confirmatory EMA-IgA test with or without human leukocyte antigen (HLA) genotyping. This evidence concerns the gene CD79A and celiac disease.