In the one-way ANOVA analysis, the statistically significant differences were observed in serum levels of IL-6, IL-17 and IL-23 related to clinical state of IBD patients (IL-6:  F3,18 = 6.74; p < 0.001; IL-17:  F3,18 = 7.54; p < 0.001; IL-23:  F3,18 = 4.65; p < 0.001) (Fig. 6). This evidence concerns the gene IL6 and inflammatory bowel disease.