No differences in the median cytokine productions were seen comparing B cell cultures of SScnoIS patients vs HD (IL-6: SSc 296.5 [171.3–493.2] pg/ml vs HD 301.2 [210.2–500.0] pg/ml, P = 0.754; IL-10: 1.0 [0.0–2.4] vs 1.2 [0.0–3.6] pg/ml, P = 0.639; IL-1β: 0.2 [0.0–3.2] vs 0.0 [0.0–0.7] pg/ml, P = 0.219; TNF-α: 14.2 [7.0–27.6] vs 20.1 [12.9–43.9] pg/ml, P = 0.165; IL12/23(p40): 0.0 [0.0–0.0] vs 0.0 [0.0–0.5] pg/ml, P = 0.471) (Supplementary Figure S2). This evidence concerns the gene IL10 and systemic sclerosis.