Both, IgA+ and IgG+ post-switched memory B cells were lower in SSc patients compared to HD (CD19+/CD27+/IgD−/IgA+: 3.0 [1.7–8.5]/μl vs 10.3 [4.9–14.7, P = 0.022. The gene discussed is CD79A; the disease is systemic sclerosis.