Increased C-to-U editing in SARS-CoV-2 has been associated with an enhanced production of inflammatory cytokines in macrophage cells (Kosuge et al. 2020), thereby potentially contributing to pathogenesis, although the corresponding effects of A-to-G changes, including on IFN signaling in COVID-19 patients, remain to be elucidated. The gene discussed is IFNA1; the disease is COVID-19.