Studies of animal reoviruses, such as that of grass carp reovirus (GCRV) that infects the grass carp (Ctenopharyngodon idella), an important freshwater fish, showed that the ADAR1 homolog is activated in response to viral infection, together with other immune response genes (Yang et al. 2012; Rao and Su 2015), implying a role in antiviral response, although its impact on the viral editing remains to be elucidated. This evidence concerns the gene ADAR and viral infectious disease.