Interestingly, AIOLOS N160S is the site homologous to IKAROS N159S, with patients carrying this particular IKZF1 mutation also displaying abnormal T and B cell phenotypes, opportunistic infections (i.e., PJP), and hematologic malignancy susceptibility (Boutboul et al., 2018). This evidence concerns the gene IKZF3 and pneumocystosis.