IKZF3 and B-cell non-Hodgkin lymphoma: Very recently, Yamashita et al. (2021) showed that the AIOLOS/IKZF3 G159R mutation is associated with B cell deficiency and recurrent sinopulmonary infections, as well as EBV infection susceptibility and B cell lymphoma, through a dominant-negative effect over both AIOLOS and IKAROS WT protein function.