It is known that both iNOS and P2X7 expression are dependent on inflammatory agents(39, 40), which indicates that there is a gap in this respect, and more studies are necessary for a better characterization and understanding of the inflammatory profile of MCs in HG conditions, but we believe that both have a common trigger in addition to stimulation by hyperglycemia. The gene discussed is P2RX7; the disease is Hyperglycemia.