Unlike patients with HGPS and LmnaG609G/G609G and LMNA G608G transgenic mice, 2 widely used HGPS models,14,26HGPSrev mice exhibit undetectable lamin A expression; however, mice that ubiquitously express lamin C and lack lamin A appeared normal,14,34,35 suggesting that lamin A absence is unlikely to provoke progeroid symptoms in HGPSrev mice. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.