In the context of TD response, the recruitment of NF-κB and STAT6 to the 5′ upstream enhancer region of Aicda locus, in addition to BATF recruitment to the 3′ downstream region, is required for the transcription of Aicda (Tran et al., 2010; Vaidyanathan et al., 2014). Here, AICDA is linked to thanatophoric dysplasia.