GRIN2C and nervous system disorder: Therefore, although therapeutics targeting NMDARs to date have largely focused on neuronal NMDARs, it would be crucial to consider also the consequences of interfering with GluN2C NMDARs that are enriched in astrocytes, which is underscored by the increasing recognition of the involvement of astrocytes in a variety of neurological disorders (Zuchero and Barres, 2015; Chung et al., 2015).