Likewise, compared to the untreated DM group, both diabetic groups treated with CNME (DM: 12.61 ± 2.12 vs. DM + CNME: 4.82 ± 0.46 pg/mL; p = 0.0002) and metformin (DM: 12.61 ± 2.12 vs. DM + Met: 6.19 ± 0.73 pg/mL; p = 0.0018) had significantly reduced TNF-α levels (Figure 3). The gene discussed is TNF; the disease is diabetes mellitus.