LYZ and inflammatory bowel disease: Intriguingly, a recent study elegantly demonstrated how endogenous lysozyme, when abundantly expressed in the colon of IBD patients, degraded colonic R. gnavus, thereby liberating its proinflammatory polysaccharide68 exaggerating intestinal inflammation.40 This novel finding presents endogenous lysozyme as a double-edged sword41 that may be tweaked by inflammatory status and microbiota composition.