Exercise increases the concentrations of several growth factors in blood, including VEGF and BDNF, which are known mediators of neurogenesis and could therefore regulate this process.[102, 207] Therefore, signaling molecules described across this review, acute exercise, and stem cells may interact, and studying the mechanisms through which they affect each other could be a promising focus of research for treatment against neurovascular disorder. The gene discussed is BDNF; the disease is neurovascular disorder.