Jagged1, one of the ligands of the Delta/Notch signaling pathway, was secreted by endothelial cells and critical for maintaining NSCs from the SVZ in a quiescent state, by inhabiting their differentiation together with EphrinB2.[6, 117] Deletion of either Jagged1 or EphrinB2 in stem cells resulted in premature activation and neuronal differentiation.[117] Another study examined the role of Notch receptors—especially Notch1, Notch3, and Notch4—in relation to neurovascular development, in the context of pancreatic cancer. Here, EFNB2 is linked to familial pancreatic carcinoma.